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5 edition of Microarray Technology and Cancer Gene Profiling found in the catalog.

Microarray Technology and Cancer Gene Profiling

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Published by Springer .
Written in English


Edition Notes

Advances in Experimental Medicine and Biology

The Physical Object
Number of Pages159
ID Numbers
Open LibraryOL7445772M
ISBN 100387399771
ISBN 109780387399775


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Microarray Technology and Cancer Gene Profiling by Simone Mocellin Download PDF EPUB FB2

Given the revolutionary implications that the use of this technology might have in the clinical management of cancer patients, principles of DNA array-based tumor gene profiling need to be clearly understood for the data to be correctly interpreted and appreciated.

Microarray Technology and Cancer Gene Profiling. Editors: Mocellin, Simone (Ed.) the implementation of Microarray Technology and Cancer Gene Profiling book array technology in cancer research has already provided investigators with novel data and intriguing new hypotheses on the molecular cascade leading to cancerogenesis, tumor aggressiveness and sensitivity to antineoplastic agents.

Given the revolutionary implications that the use of this technology might have in the clinical management of cancer patients, the principles of DNA array-based tumor gene profiling must be clearly understood for the data to be correctly interpreted and appreciated.

Buy Microarray Technology and Cancer Gene Profiling (Advances in Experimental Medicine and Biology Book ): Read Books Reviews - Microarray Technology and Cancer Gene Profiling (Advances in Experimental Medicine and Biology): Medicine & Health Science Books @   Microarray Technology and Cancer Gene Profiling Oncology Given the revolutionary implications that the use of this technology might have in the clinical management of cancer patients, the principles of DNA array-based tumor gene profiling must be clearly understood for the data to be correctly interpreted and appreciated.

Microarray Technology. Basic principle of microarray is base-pairing and hybridization [Figure 1].DNA microarray platforms for gene expression profiling were invented relatively recently, and breast cancer has been among the earliest and most intensely studied disease using this technology.

Get this from a library. Microarray technology and cancer gene profiling. [Simone Mocellin;] -- Cancer is a heterogeneous disease in most respects, including its cellularity, different genetic alterations and diverse clinical behaviors. Traditional molecular analyses are reductionist, assessing.

Francesca E. Duncan, Richard M. Schultz, Microarray Technology and Cancer Gene Profiling book Methods in Enzymology, Abstract. Gene expression profiling using microarray technology is a robust, efficient, and cost-effective approach to assay a cell or tissue's transcriptome at a particular time or under a specific condition.

Application of this technology to oocytes and preimplantation embryos has been limited largely because this.

Microarray analysis has yet to be widely accepted for diagnosis and classification of human cancers, despite the exponential increase in microarray studies reported in the literature. Among several methods available, a few refined approaches have evolved for the analysis of microarray data for cancer diagnosis.

These include class comparison, class prediction and class by: Application or technology Synopsis Gene expression profiling: In an mRNA or gene expression profiling experiment the expression levels of thousands of genes are simultaneously monitored to study the effects of certain treatments, diseases, and developmental stages on gene example, microarray-based gene expression profiling can be used to identify genes whose expression is.

When they were first introduced, DNA microarrays were used only as a research tool. Scientists continue today to conduct large-scale population studies - for example, to determine how often individuals with a particular mutation actually develop breast cancer, or to identify the changes in gene sequences that are most often associated with particular diseases.

Gene expression analysis: gene discovery ( references). Microarray technology has revolutionized studies of gene expression. A cDNA or oligonucleotide array complementary to expressed mRNA provides a means to simultaneously assess the expression of thousands of genes.

Microarray Technology and Cancer Gene Profiling, edited by Simone Mocellin, Landes Bioscience / Springer Science+Business Media, LLC dual imprint / Springer Science+Business Media, LLC series: Advances in Experimental Medicine and Biology ISBN:   Microarray technology has led the way towards global and parallel analysis of cellular processes.

The use of microarrays in transcription profiling Cited by: Gene expression profiling by microarrays – clinical implications Article (PDF Available) in British Journal of Cancer 96(2) January with 23 Reads How we measure 'reads'.

DNA microarray technology is a powerful tool that scientists and doctors can use to help predict the course of a disease for a person that has been diagnosed with cancer.

The diagnosis of cancer has generally been done by taking a biopsy of a tumor and looking at the cells under a microscope to come up with the diagnosis. Cancer Gene Profiling: Methods and Protocols examines the world of cancer gene profiling in light of these new advances, providing highly developed microarray techniques alongside modern methods for arraying tissues and proteomics.

Chapters bring together the experiences of leading scientists in each method of profiling, providing a clear. Microarray analysis, a system in which thousands of oligonucleotide sequences are spotted on a solid substrate, usually a glass slide, and RNA-derived material from a cell population is hybridized to the gene array, is an innovative technology that permits a global view of the profile of genes expressed in a cell population at a point in time.

CANCER DEVELOPMENT AND PROGRESSION Mei He, Jennifer Rosen, David Mangiameli and Steven K. Libutti Abstract Cancer Development Science/Technology Complementary Approach In Vitro/Preclinical Research Using Microarray Clinical Studies GENE EXPRESSION PROFILING IN MALIGNANT LYMPHOMAS Sarah E.

Henrickson, Elena M. Nevertheless, the recent advances in gene expression profiling technology and the important contributions of microarray technology to cancer research (the detection of Cited by: Microarray Technology: Methods and Applications, Methods in Molecular Biology, vol.

Microarray profiling of gene expression is widely applied to studies in molecular biology and. Microarrays provide a versatile platform for utilizing information from the Human Genome Project to benefit human health.

This article reviews the ways in which microarray technology may be used in breast cancer research. Its diverse applications include monitoring chromosome gains and losses, tumour classification, drug discovery and development, DNA resequencing, mutation detection and.

Let’s begin by discussing the principles of gene expression profiling and microarray technology. One of the earliest methods developed to assess gene expression in biological samples is Northern blotting, which involves “probing” for specific RNA molecules immobilized on membranes.

Gene Expression Profiling by Microarrays Clinical Implications Microarray analysis is a highly efficient tool for assessing the expression of a large number of genes simultaneously, and offers a new means of classifying cancer and other diseases. Gene expression profiling can.

Several molecular assays currently employed in the clinical assessment of breast cancer are derived from microarray-based gene expression profiling. One example of a microarray-based assay is MammaPrint (Agendia, Amsterdam, The Netherlands) or the gene prognosis profile that was approved by the Food and Drug Administration (FDA) in February.

• Part 2: DNA Microarray Technology (40 minutes) Students are introduced to microarray technology through a PowerPoint and a simulated paper microarray activity. They analyze the microarray results to compare gene expression in normal and cancerous cells.

• Part 3: Apply Your Understanding of Microarray Technology (20 minutes)*. Purpose The Microarray Innovations in Leukemia study assessed the clinical utility of gene expression profiling as a single test to subtype leukemias into conventional categories of myeloid and lymphoid malignancies.

Methods The investigation was performed in 11 laboratories across three continents and included 3, patients. An exploratory retrospective stage I study was designed for. probe set and up to 54, probe sets per microarray. Versions available for Human (U Plus ), Mouse ( ), Rat ( ), and many other spe-cies.

Affymetrix Gene ST $ In situ synthesized mer microarrays containing > million probes divided in to ~48, gene -level probe sets (human version). Provides exon and gene level.

Recently, microarray gene expression profiling has been performed to identify gene expression patterns for many solid and hematological malignancies such as colon cancer, breast cancer, prostate cancer, leukemia, and lymphoma [14–20].

Molecular profiling of RCC using cDNA microarrays has also been reported [21–26]. Using a 31,element. The use of complementary DNA (cDNA) microarray technology to explore gene expression on a global level is rapidly evolving.

Although microarray technology is still in its infancy, further investigation may prove helpful in the diagnosis, prognosis, and management of. 1 Introduction to DNA Microarrays Chris Seidel Introduction view, every gene measured on a microarray is an independent variable in a highly parallel experiment.

The number of hypotheses to which the data may or may Like strings of text in a book, the. Introduction to Gene Expression Profiling with DNA Microarray Technology. Introduction to Large-Scale Gene Expression Data Analysis. The Statistical Design and Analysis of Gene Expression Data.

Laboratory Automation for Microarray Experimentation. How to Evaluate a Microarray Scanner. Application of Microarrays to the Analysis of Gene Expression in Cancer Pascale F. Macgregor1 and Jeremy A. Squire2–4* Molecular diagnostics is a rapidly advancing field in which insights into disease mechanisms are being elu-cidated by use of new gene-based biomarkers.

Until recently, diagnostic and prognostic assessment of dis. The discovery of several types of small RNAs (sRNAs) has led to a steady increase in available RNA databases. Many of these sRNAs remain to be validated and functionally characterized. Recent advances in microRNA (miRNA)-expression profiling of different tissues, stages of development and physiological or pathological states are beginning to be explored using several technological approaches.

Microarray analysis is a highly efficient tool for assessing the expression of a large number of genes simultaneously, and offers a new means to classify cancer and other diseases.

Gene expression profiling can also be used to predict clinical outcome and response to specific therapeutic agents. Microarray‐based gene expression profiling of benign, atypical and anaplastic meningiomas identifies novel genes associated with meningioma progression.

Gunnar Wrobel. Division of Molecular Genetics, German Cancer Research Center, Heidelberg, Germany. Search for more papers by. The final version of the human genome is complete, and people everywhere are waiting with baited breath for the “genomic revolution” to get into full swing.

Pathologists have been among the first to make use of genetic data by constructing gene-expression profiles of cells and diseases with DNA microarray technology. But, according to Carlos Cordon-Cardo, a pathologist from Memorial Sloan.

Microarray Analysis of Differential Gene Expression Profile in Peripheral Microarray technology is a robust technology for gene expression profiling has been successful and increasingly popular particularly in genetics and cancer research.

There is an extensive body of clinical and ex- perimental evidence that inflammatory processes are. Whole-genome expression profiling reveals novel molecular pathways and markers for cancer progression. Over the past decade, global gene expres - sion profiling has become a standard tool for pathway and biomarker discovery.

In the past 15 years, nearly 1, peer-reviewed publications attest to the value of GeneChip® microarray technology in the. Integration of molecular profiling into the lung cancer clinic. Clin Cancer Res ;15(17)– Crossref, Medline, Google Scholar; 3 Gevaert O, De Moor B.

Prediction of cancer outcome using DNA microarray technology: past, present and future. Expert Opin Med Diagn ;3(2)– Crossref, Medline, Google Scholar.Breast cancer comprises a collection of diseases with distinctive clinical, histopathological, and molecular features.

Importantly, tumors with similar histological features may display disparate clinical behaviors. Gene expression profiling using microarray technologies has improved our understanding of breast cancer biology and has led to the development of a breast cancer molecular taxonomy.gene functions, explore new regulatory networks involved in different cellular processes.

One of the most powerful and widespread high throughput methods is the microarray technology which has become an essential tool for a new discipline studying the expression of all genes in a .